Pharmaceutical chemistry -I

General discussion on the following inorganic compounds including important physical and chemical

properties, medicinal and pharmaceutical uses, storage conditions and chemical incompatibility.

Acids, bases and buffers-Boric acid, Hydrochloric acid, Strong Ammonium hydroxide, Sodium hydroxide

and official buffers.

Antioxidants- Hypophosphorous acid, Sulphur dioxide, Sodium bisulphite, Sodium meta-bisulphite,

Sodium thiosulphate, Nitrogen and Sodium nitrite.

Gastrointestinal agents-

Acidifying agents- Dilute Hydrochloric acid.

Antacids- Sodium bicarbonate, Aluminum hydroxide gel, Aluminum phosphate, Calcium carbonate,

Magnesium carbonate, Magnesium trisilicate, Magnesium oxide, Combinations of antacid preparations.

Protective and Adsorbents- Bismuth sub carbonate and Kaolin.

Saline cathartics- Sodium potassium tartrate and Magnesium sulphate.

Topical Agents-

Protective- Talc, Zinc Oxide, Calamine, Zinc stearate, Titanium dioxide, silicone polymers.

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Antimicrobials and Astringents- Hydrogen peroxide*, Potassium permanganate, Chlorinated lime,

Iodine, Solutions of Iodine, Povidone-iodine, Boric acid, Borax, Silver nitrate, Mild silver protein, Mercury

yellow, Mercuric oxide, Ammoniated mercury.

Sulphur and its compounds- Sublimed sulphur, Percipitated sulphur, Selenium sulphide.

Astringents- Alum and Zinc Sulphate.

Dental Products- Sodium fluoride, Stannous fluoride, Calcium carbonate, Sodium meta phosphate, Dicalcium

phosphate ,Strontium chloride, Zinc chloride.

Inhalants- Oxygen, Carbon dioxide, Nitrous oxide.

Respiratory stimulants- Ammonium carbonate.

Expectorants and Emetics-Ammonium chloride*, Potassium iodide, Antimony potassium tartrate.

Antidotes- Sodium nitrite.

Major Intra and Extra cellular electrolytes-

Electrolytes used for replacement therapy- Sodium chloride and its preparations, Potassium chloride and

its preparations.

Physiological acid-base balance and electrolytes used- Sodium acetate, Potassium Acetate, Sodium

bicarbonate Inj., Sodium citrate, Potassium citrate, Sodium lactate injection, Ammonium chloride and its

injection.

Combination of oral electrolyte powders and solutions.

Inorganic official compounds of Iron, Iodine and Calcium, Ferrous Sulphate and Calcium Gluconate.

Radio pharmaceuticals and contrast media- Radio activity-Alpha; Beta and Gamma Radiations,

Biological effects of radiations, Measurement of radio activity, G.M. Counter, Radio isotopes-their uses,

Storage and precautions with special reference to the official preparations. Radio opaque contrast media-

Barium sulfate.

Quality control of Drugs and pharmaceuticals-Importance of quality control, significant errors, methods

used for quality control, sources of impurities in pharmaceuticals. Limit tests for Arsenic, Chloride, Sulfate,

Iron and Heavy metals.

Identification tests for cations and anions as per Indian Pharmacopoeia.